Journal article
Injection frequency of botulinum toxin A for spastic equinus: A randomized clinical trial
T Hastings-Ison, C Blackburn, B Rawicki, M Fahey, P Simpson, R Baker, K Graham
Developmental Medicine and Child Neurology | WILEY-BLACKWELL | Published : 2015
DOI: 10.1111/dmcn.12962
Abstract
© 2015 Mac Keith Press.Aim: We compared two botulinum toxin A (BoNT-A) injection frequency regimens, 12-monthly versus 4-monthly, for spastic equinus in a randomized clinical trial. The primary outcome measure was passive ankle dorsiflexion. Method: Forty-two ambulant children with spastic equinus, secondary to cerebral palsy (23 males and 19 females; mean age 3y 6mo, SD 13mo; GMFCS levels I [n=20], II [n=19], III [n=3]) were randomized to receive either 12-monthly or 4-monthly BoNT-A injections to the calf, over a 26-month period. Twenty-one children had spastic hemiplegia, 21 children had spastic diplegia. A fixed 6U/kg dose of Botox was injected into the gastrocnemius muscle of both limbs..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The success of this clinical trial was dependent upon the children and families involved, and the efforts of many staff and departments across the Royal Children's Hospital and Monash Children's Hospital, Melbourne, Australia. Particular thanks goes to Professor Mary Galea, University of Melbourne, Dr Nick Opie, Dr Paulo Selber, Dr Adam Scheinberg, Fiona Wilkinson, Elyse Passmore, Jessica Pascoe, Pam Thomason, Dr Jill Rodda, Karen Sosa, and staff within the neuromuscular and anaesthetic services within both hospitals. Additional acknowledgement for the support provided by the NHMRC-funded Centre of Research Excellence in Cerebral Palsy, Melbourne, Australia. The authors have stated that they had no interests that might be perceived as posing a conflict or bias.